Friday, December 20, 2013
Saturday, January 26, 2013
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IN A MALE WITH EARLY ONSET ALZHEIMER’S DISEASE and APOE 4 GENOTYPE
Reported by Mary T. Newport, MD
September 30, 2008
SJN is a 58 year old Caucasian male with early onset dementia that first became symptomatic about 6 years earlier with progressive decline over that period of time. SJN’s highest level of education was a BSBA in accounting and thereafter he worked primarily as an accountant. SJN initially presented depression and with memory related problems, such as an inability to recall if he had carried out errands that were a daily part of his job, and difficulty completing accounting tasks, such as payroll and tax returns accurately and on time. In addition he often failed to keep appointments and frequently lost important items such as his wallet, keys and shoes.
Beginning in summer 2005, he was treated with Aricept, and Namenda was added about one year later. By the fall of 2006, he was no longer able to perform any accounting or bookkeeping tasks and retired from gainful employment. Due to a 10 pound weight loss over a period of three weeks and further progression of symptoms, his medication was changed from Aricept to Exelon in September 2007. Other medications and supplements of at least two years duration include simvastatin, Lexapro, budeprion XL, and high potency fish oil capsules twice a day.
By September 2007, he could no longer prepare simple meals for himself, had discontinued driving, and required supervision to complete many other activities, such as digging a hole, replacing a light bulb, vacuuming, completing a load of laundry, doing dishes, and dressing appropriately. He was easily distracted when attempting to complete such tasks, and was no longer able to use a computer keyboard or calculator, or perform basic arithmetic. He often wore just one sock or shoe and misplaced the matches to his pairs of shoes. He also reported an inability to read, which he later (after the dietary intervention) described as excessive, erratic movement of the words on the page, had difficulty spelling simple written words, such as “out” and “put,” and had trouble recalling many common words when speaking. He also had a moderate intention-type hand tremor that interfered with eating, and a jaw tremor that was most apparent while speaking. He had an abnormal gait that involved walking slowly and pulling each foot up higher than usual with each step.
An MRI in May 2008 showed diffuse involutional change of the frontal and parietal lobes and moderate left-sided and severe right-sided amygdala and hippocampal atrophy with no ischemic change, supporting a clinical diagnosis of Alzheimer’s Disease. At the same visit, he scored 12 of 30 points on the Mini Mental Status Exam (MMSE.)
On May 20, 2008, the day prior to the dietary intervention, he scored an MMSE of 14 out of 30 points, and drew clock #1.
On May 21, 2008, SJN was given at least 35 ml of coconut oil, equivalent to about 20 grams of medium chain triglyceride (MCT oil) with breakfast. Approximately 4 hours later he scored 18 of 30 points on the MMSE, gaining points in the areas of orientation to time and place. 14 days after beginning use of coconut oil, SJN drew Clock #2 and at 37 days Clock #3. Blood work sent on 5/21/08, showed that SJN carries at least one APOE4 allele.
He continued to receive a minimum of 35 ml coconut oil for breakfast and, a second quantity of at least 35 ml was routinely added to the evening meal by 6/24/08 and thereafter .
On 7/2/08, SJN scored 17 of 30 on the MMSE at a different location than the previous exams. On 7/11/08, plasma ketones and glucose were determined immediately before breakfast and at 90’, 120’ and 180’ after receiving 35 ml coconut oil with breakfast, and immediately before the evening meal and at 60’, 120’, and 180’ after receiving 35 ml coconut oil, with the results shown in Table 1 and Graph 1. Levels of ketones increased after the breakfast dose of coconut oil, peaking at about 3 hours and then returning to baseline (almost “0”) prior to the evening meal. A third amount of at least 35 ml coconut oil was added to the lunchtime meal, in order to keep a continuous level of circulating ketones available.
For comparison, on 7/24/08, plasma ketone levels were drawn at approximately the same time of the morning as in the 7/11/08 study, immediately before, and at 90’, 60’ and 180’ after receiving 22 ml (20 gm) of Neobee 895, a pure C:8 medium chain triglyceride oil, with significantly higher levels of beta-OH butyrate, as shown in Table 2 and Graph 2. Also in the afternoon of 7/24/08, SJN scored 20 out of 30 points on the MMSE.
Over the next six weeks, MCT oil in the diet was increased gradually to 40 ml three times a day with meals, and coconut oil was decreased to an average of 15 ml twice a day, primarily used in cooking. There were no adverse effects noted with ingestion of coconut oil, however there were occasional brief episodes of explosive diarrhea (2-3 times per week) that occurred after arriving at the 40 ml quantity of MCT oil, which have become less frequent.
In addition to the improvement in MMSE scores, the author/spouse/caregiver reports that SJN has experienced the following improvements: absence of facial tremor, and minimal to no intention tremor involving the hands; normalization of gait; improved memory of recent and past events; ability to complete household and gardening tasks with minimal to no supervision and without distraction; he now wears both shoes and socks, and keeps pairs of shoes together; his ability to initiate and continue a course of conversation has improved and his sense of humor has returned. SJN also reports an increase in libido, an interest in exercise, and a desire to relearn basic skills, such as writing, math, and touch-typing. He requested that a watch be purchased so that he could relearn how to tell time, and wears the watch regularly, after not wearing a watch for at least two years. He also reports the absence of visual disturbances, with a marked improvement in his ability to read, as evidenced by successfully reading out loud from new articles.
On September 28, 2008, he recalled that he began to have problems functioning at the same level as early as ages 28-30 years old in his job as an accountant and business manager for a mental health, mental retardation regional center. A study of persons at risk for early onset AD demonstrated decreased uptake of glucose on PET scans of APOE4 people as early as 30 years of age. About twelve weeks after beginning the coconut oil intervention, he could not remember how to turn on a computer and was unable to recall how to use a “mouse,” nor did he recall the concepts of “left” or “right-clicking.” On September 29, 2008, about 18 weeks after beginning the coconut oil intervention, he turned the computer on and opened up an accounting program, using the mouse appropriately, without prompting. In addition, he has stated on several occasions that he has “gotten (his) life back,” and expresses hope for his future.
Mary T. Newport, MD
10030 Orchard Way
Spring Hill, FL 34608
Sunday, September 13, 2009
I have downloaded a number of internet marketing e-books in the past. I can say most of them are meaningless books that are jam-packed with fluff and that they are overpriced. What makes me lost hope in internet marketing was the fact that most of the so-called gurus are merely rephrasing and repackaging basic content and techniques which I can easily search online for free. I mean, come on!
I was seriously tired of buying and reading junk articles which I had paid a large sum for until I stumbled across Authority Resell Mastery by Alvin and Joel.
I have to admit that the first thing which I looked for when I stumbled upon the website was the price. In fact, I did that to everyone product page which I encounter as I like to cut the chase short by knowing how is it selling for. I believe it is just a form of defensive mechanism which I have developed in order to avoid the marketing gimmicks and tricks by skillful copyrighters as I do have my experience in internet marketing before.
What hits me next was utterly shocking. The whole package costs a measly $9.97 only! I was very skeptical as I believe that you get what you paid for. It is too cheap to be a quality product in my first thoughts. I kept asking myself how anyone can even bother to price the product as such a low price and expect people to believe that it is value for money. Well, in the end, I decided to give it a short in reading the sales letter.
First of all, the manuals are written by Alvin Huang and Joel Chue. I have heard of Alvin Huang as one of the most successful internet entrepreneurs in Singapore. He was featured on a number of major local newspapers and his clients consisted of big names such as Visitors Singapore and Fine Grain Property. Well, in short he is the real deal. He and his partner, Joel Chue, have shown impressive joint venture deals with some of the big guns in the internet marketing world. One can never doubt their credentials and achievements.
For that reason alone, I decided to give the Authority Resell Mastery a try as I was also covered by their 60-day money back guarantee. In fact, I have noting to lose as I can get a refund back.
Once I have downloaded the three e-books plus their bonus, I was impressed by the amount of content in the e-books. It is really jam-packed with lots of information regarding the nuts and bolts of building an online empire using e-products with resell rights. The three books are structured differently and that it is progressive. What I really like is that it is easy for beginners to understand and follow.
Besides that, e-books contained a lot of valuable and most importantly practical information on how to first find an excellent niche market that has a highly profitable potential and how to find quality e-products that has resell rights or create your own e-books. The authors also explain the possible ways for you to repackage the e-books as well as creating your own physical products. They even go to the extent of showing how to deliver your physical products by automatic, hands-free! That is a valuable piece of information that is rarely available in most other internet marketing e-books.
What I love most about the whole package is the traffic-generating techniques which are extensively covered in book 3. They covered the various ways to market your website and product in order to drive truck loads of traffic to your website within a few hours. They even showed how their sneaky video marketing tactics enable them to consistently position themselves in the first page of the Google search page.
In short, I strongly recommend that any serious internet marketers get a hold on their ground-breaking e-books fast before your competitors do. I can safely say that $9.97 for such high quality e-books is a ridiculously low price for everybody to take advantage of immediately.
Monday, June 29, 2009
Affiliate marketing has its ups and downs. It could be draining if you are not armed with updated information and the technical how-tos. But this article's sole objective is to reach out to you and not to badmouth affiliate marketing.
Here are the following reasons on why web marketers go gaga over affiliate marketing as a form of Internet advertisement.
1. Low cost
Many are scared to go on a home based business because of the capital required. In affiliate marketing, you don't have to spend much to start raking in moolah.
2. Inventories not included
Product management fuss could be very stressing. An inventory is not asked to be maintained. The merchant does the maintenance required.
3. Unlimited income through leverage
When you have a paid job, your monthly income mainly relies on whether you go to work or not. With affiliate marketing, your affiliates could all just lead traffic to your site without having to lift a finger after providing them your ad copy and links. Though not every web marketer earns limitless, it still is a fact that all the necessary matters for the advertiser or Internet marketer are all there to be successful.
4. Go worldwide
With affiliate marketing, you are dealing with a global market place. All you have to do is choose a niche product and prepare all the necessary tools for your affiliates to lead traffic from just about anywhere to your website.
5. Low risk
The very main reason for Internet marketer's enthusiasm with affiliate marketing is its having a low risk factor. Especially for those with low budget set aside for advertising, affiliate marketing is just the way to do it.
6. No closing time
With affiliate marketing, your business works every single second of the day while targeting a worldwide market! What could be better than that?
But all of these will be put to waste if you don't have the right niche product and all the other important tools to make it big in affiliate marketing, i.e., well-SEO-ed website. So better work on this first before ever considering those benefits.